A small number of studies have reported that acute social isolation promotes subsequent social interaction in rodents, but it remains unknown whether the production of social USVs is similarly enhanced during social encounters following acute isolation. However, much less is known about how rodent social behavior is affected by short-term social isolation. Many studies have also reported effects (or lack thereof) of chronic social isolation on the production of ultrasonic vocalizations (USVs), which many rodents emit during same-sex and opposite-sex social encounters. As in humans, chronic social isolation in rodents leads to increases in anti-social behaviors, including increased anxiety, increased aggression, and decreased social motivation. Rodents are frequently used as a model to understand how social isolation impacts emotional states and engagement in social behaviors in humans. Consequently, the experience of social isolation is aversive and increases our motivation to seek out and engage in social interactions. We find social interactions intrinsically rewarding, and we are highly motivated to seek out social contact and to form and maintain social bonds. Social interactions form the backbone of our experiences as humans. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All data associated with this study are made available through Cornell eCommons ( ).įunding: This research was supported by a research grant from the Cornell Center for Social Sciences (awarded to K.A.T.). Received: ApAccepted: JPublished: September 1, 2021Ĭopyright: © 2021 Zhao et al. (2021) Sex- and context-dependent effects of acute isolation on vocal and non-vocal social behaviors in mice. Our findings advance the study of same-sex interactions between female mice as an attractive paradigm to investigate neural mechanisms through which acute isolation enhances social motivation and promotes social behavior.Ĭitation: Zhao X, Ziobro P, Pranic NM, Chu S, Rabinovich S, Chan W, et al. Our experiments uncovered pronounced effects of acute isolation on social interactions between female mice, while revealing more subtle effects on the social behaviors of male mice during same-sex and opposite-sex interactions. To address these questions, we characterized the effects of acute (3-day) social isolation on the vocal and non-vocal social behaviors of male and female mice during same-sex and opposite-sex social interactions. While the effects of chronic social isolation on mouse social behavior have been well studied, much less is known about how acute isolation impacts mouse social behavior and whether these effects vary according to the sex of the mouse and the behavioral context of the social encounter. Mice are frequently used as a model to understand how social isolation impacts the brain and behavior. Humans are extraordinarily social, and social isolation has profound effects on our behavior, ranging from increased social motivation following short periods of social isolation to increased anti-social behaviors following long-term social isolation.
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