![]() We recently developed a mathematical approach for rapidly modeling economic demand in rats trained to self-administer cocaine within a single 110-min session ( 8). Finally, we found that economic demand for cocaine predicted the efficacy of a promising pharmacotherapy (oxytocin) in attenuating cocaine-seeking behaviors across individuals, demonstrating that economic measures may be used to rapidly identify the clinical utility of prospective addiction treatments. They also support the view that excessive motivation plays an important role in addiction while extending the idea that drug dependence represents a shift from initially recreational to compulsive drug use. ![]() ![]() These findings confirm economic demand as a biomarker of addiction-like behavior in rats. We show here that economic demand, as both a spontaneous trait and induced state, predicts addiction-like behavior, including relapse propensity, drug seeking in abstinence, and compulsive (punished) drug taking. We recently developed a mathematical approach for rapidly modeling economic demand in rats trained to self-administer cocaine. However, economic demand has not yet been established as a biomarker of addiction-like behavior in animals, an essential final step in linking animal and human studies of addiction through economic models. They offer a structured quantitative approach to modeling behavior that is mathematically identical across species, and accruing evidence indicates economic-based descriptors of human behavior may be particularly useful biomarkers of addiction severity. Economic models are promising candidates. ![]() However, an addiction biomarker fit for rapid testing, and useful in both humans and animals, is not currently available. Development of new treatments for drug addiction will depend on high-throughput screening in animal models. ![]()
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